VITAMINS Trial: Vitamin C and Thiamine for Sepsis and Septic Shock

A randomized trial of 24 patients showed that high-dose IV vitamin C attenuated organ failure associated with sepsis in a dose-dependent manner. In 2020 a larger trial reported no difference in duration of time alive and free of vasopressor administration at 7 days among intensive care unit (ICU) patients with septic shock assigned to vitamin C, thiamine, and hydrocortisone vs those assigned to hydrocortisone alone.

Tomoki Fujii, PhD, of Monash University in Melbourne, Australia, and Kyoto University Graduate School of Medicine in Japan, presented findings from the VITAMINS Trial (02:15) at the Critical Care Reviews 2020 meeting (CCR20), on January 17 in Belfast, Northern Ireland.

An oral editorial from Paul Marik, MD, of East Virginia Medical School (33:00) and a Q&A session (57:25) follow.

Click for full trial details.

Video used with permission.

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